![]() No significant between-group differences existed for Center B. At Center B, the mean objective score consistently and significantly decreased with Marvelon after 3 and 6 treatment cycles (p 0.05 and p 0.01, respectively) and with Diane after 6 treatment cycles (p 0.001). At cycle 6, the mean objective score for Diane was much lower than that for Marvelon (p 0.05). This decrease was significant with Diane after 3 and 6 treatment cycles (p 0.05). The mean objective acne score decreased with both OCs in Center A. The study consisted of a baseline cycle and 6 successive treatment cycles. All the women presented with acne and were between 16 and 30 years old. In Thailand, at the Prince of Sonkhla University in Sonkhla (Center A) and Rajvithi Hospital in Bangkok (Center B), researchers compared data on 32 women using a low-dose combined oral contraceptive (OC) containing 150 mcg desogestrel plus 30 mcg ethinyl estradiol (Marvelon) with data on 34 women using an OC containing 2000 mcg cyproterone acetate plus 50 mcg ethinyl estradiol (Diane) to examine their efficacy in acne treatment. Both preparations increased plasma levels of sex hormone binding globulin and seemed to decrease those of total and free testosterone, but no statistically significant relationships between acne severity and biochemical variables could be detected.īoth Marvelon and Diane are effective in the treatment of acne in Oriental women who also need reliable contraception, without marked differences between the preparations. The decrease in percentage of severe/moderate acne was statistically significant with Marvelon in Center B (P = 0.002) and with Diane in Centers A (P = 0.014) and B (P = 0.004). There were no significant between-group differences. 01) and with Diane after six treatment cycles (P <. ![]() In Center B, a consistent and significant decrease in mean acne score was observed with Marvelon after three and six treatment cycles (P <. In addition, there was a significant between group difference at cycle 6 (P <. In Center A, with both preparations a decrease in mean objective acne score was observed, reaching statistical significance with Diane (P <. The measured variables were objective and subjective severity of acne, and related biochemical variables such as sex hormone-binding globulin and free and total testosterone. ![]() In an open-label, bi-center, randomized study, 32 women using Marvelon and 34 using Diane were followed for 6 treatment cycles. The drug was pulled off the market in 2009 after evidence emerged of hundreds of deaths caused by damage to heart valves.ĭiane-35 is sold in 116 countries around the world, according to the ANSM website.To compare the effects of a low-dose oral contraceptive containing desogestrel (Marvelon) and an anti-androgenic preparation containing cyproterone acetate (Diane) in Oriental women suffering from acne. Health experts disagree on the risks, though.Īnother scandal concerns an anti-diabetes drug called Mediator, manufactured by the French pharmaceutical company Servier, which started being used as a slimming aid because it reduces hunger pangs. In 2010, the French authorities called down breast implant manufacturer Poly Implant Prothese (PIP) after it was found to be using non-authorised silicone gel that caused a high rate of implant ruptures. It has asked the European Medicines Agency (EMA) to change prescription guidelines for so-called third- and fourth-generation oral contraceptives after these drugs were found to carry a higher risk of blood clots compared to earlier versions. Over 25 years, four women have died from blood clots attributed to Diane-35, according to ANSM, which said more than 300,000 women in France are using it as a contraceptive.įrance has been shaken by a series of health scares in recent years. yet there are plenty of other alternative contraceptives that can be used in this country." "(.) But it is being used as such, in this secondary role. "This drug is not licensed for use as a contraceptive," Maraninchi said. The product is authorised for treating acne in young women, but doctors have been prescribing it as a contraceptive because it stops ovulation, he said. The move will be phased in over three months to allow users to find an alternative drug, Dominique Maraninchi, the agency's director, told a press conference. The National Agency for the Safety of Drugs and Health Products (ANSM) said it was suspending sales of a hormonal treatment called Diane-35 made by German firm Bayer. It is the latest health scare to erupt in France, coming after controversies involving later-generation contraceptive pills, breast implants and a pill used as a dietary aid that was linked to heart failure. ![]() ![]() France on Wednesday suspended sales of an acne drug whose use as a birth control pill has been linked to the deaths of four women. ![]()
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